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Quorum sensing inhibition to restrain bacteria

Bacteria use a cell-to-cell communication system called quorum sensing (QS) to share information about cell density and adjust gene expression accordingly. This article explains BASF studies into how natural plant extracts are able to quench QS signals from P. aeruginosa and S. aureus. Then, it checked if their effect on QS was followed by a decrease in virulence, determined by both bacteria motility and lipase secretion

Bacteria use a cell-to-cell communication system called quorum sensing (QS) to share information about cell density and adjust gene expression accordingly.1 QS controls genes that direct activities that are beneficial when performed by groups of bacteria acting in synchrony.2

Processes controlled by QS include antibiotic production, biofilm formation, and virulence factor secretion are responsible for harmful bacterial expression in body and on human skin. QS systems rely on the production and sensing of extracellular signals.1

In our investigations, we focused on two bacteria. The first one is Pseudomonas aeruginosa, a gram-negative-bacteria, known to be involved in skin infection, in green nail syndrome and less severe conditions like folliculitis, and skin rashes. 

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Upcoming Events

in-cosmetics Global

Paris Expo Porte de Versailles
16th – 18th April 2024

NYSCC Suppliers' Day 2024

Javits Center, New York
1st - 2nd May 2024

9th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
25th - 26th June 2024

in-cosmetics Korea 2024

Hall C, Coex, Seoul, South Korea
24th - 26th July 2024

in-cosmetics Latin America 2024

São Paulo, Brazil
25th - 26th September 2024

IFSCC 2024

Recanto das Cataratas Thermas Resort, Iguazu Falls, Brazil
14th - 17th October 2024

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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