Showcasing timeless beauty

Facial expressions help communicate our emotions and connect us to others. But over time, those smiles and frowns can be recorded on our skin, in the form of mimic wrinkles.

SYN-AKE from DSM is the needle-free solution to this type of wrinkle. This unique tripeptide helps relax the skin from within, for smoother skin and a younger-looking complexion. DSM have recently released some formulations showcasing the ingredient which empower mothers and daughters to find the best solution for preventing and reducing wrinkles.

It visibly reduces deep wrinkles, and when used earlier in time it helps delay their appearance with an age freezing effect.

Mode of Action

SYN-AKE is a patented tripeptide, with unique mechanism of action. Its mimics the essential amino acid sequence of the Waglerin-1 functionality, a naturally occurring polypeptide found in temple viper venom, with a strong ability to relax muscle contraction.

The effect of SYN-AKE focuses on an immediate and lasting relaxation of mimic wrinkles. In vitro, the peptide cosmetic ingredient is considered as an antagonist at the muscular nicotinic acetylcholine receptor (mnAChR). As the muscular nicotinic ACh receptors are reversibly blocked, the ion channel remains closed. There is no uptake of Na+ and the muscle cells stay relaxed and consequently facial wrinkles as well.

Seeing is believing

A novel facial colour map demonstrates that SYN-AKE helps visibly to reduce expression lines and wrinkles. The more intense the color on the map highlights the greater improvement in wrinkle severity.

Discover the powerful pro-ageing tripeptide, designed for mothers & daughters

Our mothers offer a window into our future. Over time we realise… we’re more alike than we thought, and we are proud to be like them. Every smile and every frown we exchange in life leaves its mark on both our faces, from expression lines to mimic wrinkles.

SYN-AKE is clinically proven to:

• Help skin to relax from within for a smoother complexion

• Visibly reduce deep wrinkles by -20% in just 4 weeks

• Prevent the appearance of wrinkles with age-freezing effects

After all, life should be about expressions – not wrinkles!

Curious? Download DSM's ready to use formulations empowering mothers and daughters to find the best solution for preventing and reducing wrinkles

Latest Issues

Society of Cosmetic Chemists 78th Annual Scientific Meeting & Showcase

JW Marriot Los Angeles L.A. LIVE
11th - 13th December 2024

PCHi 2025

China Import and Export Fair Complex Guangzhou
19-21 February 2025