Lenitive and antiphotoageing properties of C.asiatica Plant-derived elements used for pharmacological applications constitute an increasing research field. An interesting study from Italian researchers investigated a new purified extract from Madagascar gotu kola [Centella asiatica (L.) Urban] as a novel anti-inflammaging and antiglycation agent for use against skin wrinkling and for skin protection against UV exposure.
The results of this study qualify C. asiatica purified extract as an anti-ageing ingredient, addressing skin damage caused by inflammaging and glycation by relying on the synergy of triterpens and polyphenolics.
The C. asiatica extract used in the trial is Indena CentevitaTM (Indena SpA, Milan, Italy). The form of extract is a greenish powder containing all four typical centella terpenoids asiaticoside, madecassoside, asiatic acid and madecassic acid (Fig. 1) (not less than 45%) as well as a polyphenolic fraction (over 7%). Madecassoside is the only centella triterpenic compound which has shown the capability to promote collagen type III production, whereas asiaticoside, asiatic acid and macedassic acid are reported to promote the synthesis of collagen type I1 with a major potency being reported for madecassoside.2
The extract has been tested in vitro and clinically with the aim of investigating its overall biological activity both on human skin explants maintained alive as well as clinically in healthy volunteers enrolled in the study.
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