To reduce the gravitational signs of ageing, Evonik launched Sphingokine NP at in-cosmetics 2012. This latest active is based on Evonik’s sphingolipid technology. The unique short-chain ceramide Sphingokine NP was found to stimulate the cross-talk between cells throughout the skin.
By this it provides multilayer activity improving the state of the various skin layers. Due to deep penetration of Sphingokine NP, the molecule can reach all different skin layers from the epidermis to the dermis and even the subcutaneous tissue. Various in vitro studies have shown that Sphingokine NP functions in the epidermis as a signalling molecule for keratinocyte differentiation. This leads to strengthening, densifying and smoothing effects of the stratum corneum, the protection barrier of the human skin. In addition, factors that stimulate dermal cells (fibroblasts) are induced by Sphingokine NP, leading to improved communication between keratinocytes and fibroblasts and dermal matrix stimulation by keratinocyte-derived signals. In the dermal parts of the human skin, Sphingokine NP supports the dermal scaffold function by inducing fibroblast-derived signals for improved ECM (extracellular matrix) organisation. In addition, dermal matrix formation is stimulated by keratinocyte- and adipocytederived signals. Thus, Sphingokine NP tightens the skin structure and tones skin tissues.
