Developing efficient probiotics in ageing

Magnitude Biosciences explains why Caenorhabditis elegans (C. elegans), a small nematode worm, offers insights into specific age-related outcomes of exposure to probiotics in the gut-skin axis, and provides the perfect bridge between animal models and cell models

With ageing a growing concern for many populations around the world, researchers in the personal care industry are constantly trying to understand how to solve age-related skin problems including wrinkles, pigmentation, and dryness. The gut-skin axis has been identified as an important bidirectional relationship between the gut microbiome and skin health, with recent studies suggesting that the gut microbiome can influence skin health.

The dysregulation of the microbiome has been seen in numerous inflammatory skin conditions such as atopic dermatitis, rosacea, and psoriasis.1 Understanding how the gut microbiome is involved in regulating skin health may lead to development of treatments for these skin disorders through microbiome adjustment.

Improving skin health through probiotics is becoming a popular concept and by regulating skin health and gut—skin axis interactions, probiotics have the potential to be used as tools to suppress and improve skin diseases in multiple ways.

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