Benefits of solubilized azelaic acid on C. acnes

Vantage has developed a new form of azelaic acid in which the acid is presolubilized in a mild skin emollient. It has been shown that delivery of dissolved azelaic acid can show superior performance to suspended azelaic acid and can help to improve the inflammatory effects of topically applied salicylic acid

Acne is a skin condition that affects individuals throughout their lives. The causes of acne are complex and are principally based on a person’s genetics while a person’s age, eating habits, hygiene, and hormonal changes among other etiologies can also play a significant role in the progress of the disease.1

However, emerging now is a more nuanced understanding of the causes of acne that appear to be linked to the skin's innate immunity and the communication between the skin's living cells, including epithelial and immune cells, and Cutibacterium acnes (C. acnes), a known skin commensal that is associated with acne.2,3

More profoundly, it now appears that acne may have a relationship to various acneic strains of C. acnes, so called bad C. acnes, against strains that are known to be less pathogenic.4 A recent publication noted that one of the key drivers of acne inflammation is the Tumor Necrosis Factor (TNF-a) pathways of inflammation.5

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