Restoring skin with a novel Ca2+ delivery system

ABSTRACT

Ageing and metabolic disorders such as diabetes are key drivers that can lead to skin barrier disruption. Despite the increasing demand for cosmetic treatments for old/diabetic skin, current options are limited and often include occlusive formulations. A major characteristic of a disrupted skin barrier is a defective calcium gradient in the epidermis. Therefore, replenishing the aged/diabetic skin’s calcium stores with topical calcium could be a potential therapeutic approach. Both in vitro and clinical studies have shown, that a novel calcium ion (Ca2+) vector system enables the successful delivery of bioavailable Ca2+ ions into the skin, aiding not only in recovery but also in protection of the skin from SLS stress. This highlights the use of this vector system as a new and superior approach to treat a damaged barrier present in diabetic, aged, or atopic skin.

Our skin’s epidermis acts as an essential and strong natural barrier that protects our body. It prevents the entry of pathogens, allergens, and environmental pollutants while at the same time sealing in water, ensuring proper moisture levels in the skin. Damage to the epidermal barrier can have dramatic effects on our skin, leading to dry, irritated, and scaly skin, in extreme cases even xerosis