Targeting the Ah receptor: a new antipollution strategy

Today’s lifestyles expose the body to all sorts of constant environmental stress which is difficult to avoid in a continuous and efficient way.

Urban pollution, chemicals and cigarette smoke damage the skin and gradually lead to its premature ageing. Skin cells detect pollutants thanks to molecular detectors such as aryl-hydrocarbon receptors (AhR). Once activated, the AhR regulates the expression of target genes, such as CYP1A1 (or aryl hydrocarbon hydroxylase). The sustained induction of the AhR-CYP1A1 pathway through daily exposure to environmental pollutants is responsible for the harmful pollution-related effects. 

An active ingredient obtained from dandelions Taraxacum officinale (dandelion) extract (TE) has been developed to regulate activation of the AhR-CYP1A1 signalling pathway. In addition, in vivo studies have shown that TE reduces levels of oxidised proteins and improves the complexion radiance. 

This active ingredient restores the skin’s natural protective shield. It is recommended for all skin care products intended to attenuate the harmful effects of pollution.

Log in or register FREE to read the rest

This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text. If you don't already have an account, please register with us completely free of charge.

Latest Issues

Society of Cosmetic Chemists 78th Annual Scientific Meeting & Showcase

JW Marriot Los Angeles L.A. LIVE
11th - 13th December 2024

PCHi 2025

China Import and Export Fair Complex Guangzhou
19-21 February 2025