Neuron ageing and its effect on skin homeostasis

Initiated in the 2000s, ‘neurocosmetics’ refers to topical ingredients that work on the cutaneous nervous system to restore the mediator-receptor balance in the epidermis. It has led to new ways of inducing a positive action on the skin’s nervous system which results in increased skin health.

In 2014 scientists discovered that our touch experiences are processed by neurons in the skin before they reach the brain for further processing.

Meanwhile it has been demonstrated that human skin loses its cutaneous sensitivity with age due to an ageing of sensory fibres in the skin. We know that in the dermis, fibroblasts and neurons are continuously communicating. 

Can ageing of sensory fibres impact fibroblasts and therefore skin youth? Working on specific nerves culture models, Codif R&N has highlighted that neuroageing leads to the release of toxic molecules that directly affect fibroblast activity. 

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