Communication between cells within a certain skin layer, but also across various skin layers and between different skin cell types, is imperative for the proper function of skin.
The unique short-chain ceramide caprooyl phytosphingosine (trade name Sphingokine NP) was found to stimulate the cross-talk between different cells throughout the skin, resulting in visibly plumped and reshaped skin.
Sphingolipids contribute to approximately 50% of the strateum corneum lipids, predominantly in the form of ceramides. They function as building blocks of the epidermal barrier as well as regulators of diverse cellular processes. Breakdown products of naturally occurring ceramides (sphingosine, sphinganine and phytosphingosine) and their metabolites along with ceramides themselves were identified as regulators of keratinocyte function.
In a large screening study, Paragh et al.1 have demonstrated that short-chain ceramides, like caprooyl phytosphingosine, significantly stimulate skin cell differentiation in cell culture.
The multilayer activity of short chain ceramide caprooyl phytosphingosine was later demonstrated by Evonik in a range of in vitro skin models, including proliferating human epidermal keratinocytes, human dermal fibroblasts as well as human adipocytes. Extended in vivo studies have confirmed that caprooyl phytosphingosine improves the state of the various skin layers.
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