Lipotec’s research on anti-ageing has recently put the focus on the anti-pollution properties of the well-known antioxidant ingredient Lipochroman synthetic molecule.
The recent in vitro results have showed a reduction by 99.3% of DNA damage induced by pyrene, one of the most abundant and harmful air pollutants. Upon photoactivation by UVA and/or visible light, pyrene potentiates reactive oxygen species that induce single strand DNA breaks.
While prevention is a key function of skin care products, protection against environmental factors such as external pollutants (UV, pollution and smoke) continues leading innovation within the cosmetic market. Major pollutants in the air include sulphur oxides, nitrogen oxides, carbon monoxide, ozone, heavy metals and organic aerosols, which contain powerful atmospheric pollutants, known as polycyclic aromatic hydrocarbons, such as pyrene. When these pollutants are exposed to other environmental factors such as UV as well as endogenous elements, they create a source for the generation of free radicals.
Reactive species are highly prejudicial for the skin cells and structural components, accelerating premature ageing. An imbalance between the production of reactive species and the skin endogenous antioxidant defense system produces stresses that damage the skin at different levels. Oxidative stress is involved in the damage of cellular constituents such as DNA, cell membrane lipids or proteins.
The research of Lipotec in skin prevention has led to numerous patented peptides and synthetic molecules addressed at modulating proteotoxic stress and preventing cellular damage due to free radicals generated by intrinsic and extrinsic stimuli. Among them, LIPOCHROMAN® synthetic molecule has dual scavenging properties (ROS and RNS) and helps to protect cells from irreversible damage while preserving cellular viability against oxidative stress.
With proven excellent long term stability when compared to other well-known antioxidants, Lipochroman synthetic molecule has shown in vitro an antioxidative effect greater than resveratrol, vitamin E and ferulic acid and a photoprotective profile. In today’s environment, protection against the impact of pollution, stress and UV is a continued area of focus in skin care products the new anti-pollutants study completes its shielding profile to meet increasing consumer awareness on age-prevention.
