Marlies Regiert – Wacker Chemie AG, Germany
Cyclodextrins (CDs) are probably the most commercially important example of compounds that form host-guest complexes. In the cosmetic industry this ability of CDs to form inclusion complexes with a broad variety of organic compounds is used to increase stability and solubility of cosmetic actives and also decrease sensitivity to light and oxidation. The non-covalent inclusion complexes can have physical, chemical and biological properties that are dramatically different from those of either the parent cosmetic actives or cyclodextrins.
Materials and methods
Materials
Retinol was purchased from BASF, d-alpha Tocopherol (Copherol F1300) from Cognis and Linoleic acid from Aldrich. a- and g-Cyclodextrin are products of Wacker Chemie AG, Munich, Germany.
Methods
The inclusion compounds were prepared from concentrated cyclodextrin solutions or by the kneading method with the exclusion of light and under nitrogen atmosphere. The complexes were isolated by filtration, followed by a washing step with deionised, nitrogen saturated water and finally dried at 30-40°C in vacuum.
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