Marine minerals in the dermal matrisome

Research at Oriel Marine has highlighted the beneficial effect of deep-sea minerals on the skin

n recent decades, both anti-ageing and biomedical research have focused intensely on the biochemistry and pathophysiology of the extra-cellular matrix (ECM), as well as on matrix dysregulation, which can underpin skin pathophysiology.1,2 The ECM fills the intercellular space and is present in all connective tissues including that of the integumentary system.

Within the intercellular space, phenomena like cellular polarisation and migration, regulation of growth factors, activation and modulation of signalling transduction and gene expression, and processes translating mechanical stimulation into a biochemical signal through the involvement of mechanosensitive channels are all essential for the maintenance of ECM elasticity, dermal tissue architecture and tone. Mechano-transduction in particular, is an increasingly well-studied process, and regulates cellular ‘tensegrity’, an emerging field of mechanobiology.3

Hyaluronic acid

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