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New approach to suppressing wrinkles

Ichimaru Pharcos has developed peppermint leaf extract as a raw cosmetic ingredient that shows wrinkle improvement effects by suppressing the rise in eATP concentration in the skin

Skin-thinning in aged skin is considered an important factor in the formation of wrinkles. Due to natural ageing of the epidermal keratinocytes, there is a remarkable production of senescenceassociated secretory phenotype (SASP) factor, which induces matrix metalloproteinase-1 production in dermal fibroblasts, resulting in dermal thinning. Meanwhile, extracellular ATP (eATP) is known to induce the production of SASP factors, but the relationship between eATP and natural ageing is unknown. In this study, we showed the relationship between the increase of eATP in the epidermis and the dermal thinning seen with natural ageing. Peppermint leaf extract (PME) effectively suppressed the rise in eATP concentration due to natural ageing and environmental stress. Furthermore, PME suppressed skin thinning and improved various wrinkles, such as crow’s feet and neck wrinkles. These results suggest that PME is an antiageing material that suppresses eATPmediated dermal thinning and effective

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Upcoming Events

in-cosmetics Formulation Summit

Leonardo Royal Hotel, London
29 - 30 November

SCC 75th Annual Scientific Meeting & Showcase

Sheraton NY Times Square (New York)
13-15 December 2021

in-cosmetics Global 2022 - Paris

1 Pl. de la Porte de Versailles, Paris
5 - 7 April 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Asia 2022

BITEC Bangkok, Thailand
1 - 3 November 2022

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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