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New approach to suppressing wrinkles

Ichimaru Pharcos has developed peppermint leaf extract as a raw cosmetic ingredient that shows wrinkle improvement effects by suppressing the rise in eATP concentration in the skin

Skin-thinning in aged skin is considered an important factor in the formation of wrinkles. Due to natural ageing of the epidermal keratinocytes, there is a remarkable production of senescenceassociated secretory phenotype (SASP) factor, which induces matrix metalloproteinase-1 production in dermal fibroblasts, resulting in dermal thinning. Meanwhile, extracellular ATP (eATP) is known to induce the production of SASP factors, but the relationship between eATP and natural ageing is unknown. In this study, we showed the relationship between the increase of eATP in the epidermis and the dermal thinning seen with natural ageing. Peppermint leaf extract (PME) effectively suppressed the rise in eATP concentration due to natural ageing and environmental stress. Furthermore, PME suppressed skin thinning and improved various wrinkles, such as crow’s feet and neck wrinkles. These results suggest that PME is an antiageing material that suppresses eATPmediated dermal thinning and effective

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Upcoming Events

in-cosmetics Korea 2022

Hall C, Coex, Seoul, South Korea
13 - 15 July 2022

PCHi China 2022

Shanghai World Expo Exhibition & Convention Center
18 - 20 July 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Latin America 2022

Expo Center Norte, Sao Paulo
21 - 22 September

Cosmetorium 2022

Palau de Congressos de Barcelona
28 - 29 September

SEPAWA 2022

Estrel Congress Center, Berlin
26 - 28 October

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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