New approach to suppressing wrinkles

Skin-thinning in aged skin is considered an important factor in the formation of wrinkles. Due to natural ageing of the epidermal keratinocytes, there is a remarkable production of senescenceassociated secretory phenotype (SASP) factor, which induces matrix metalloproteinase-1 production in dermal fibroblasts, resulting in dermal thinning. Meanwhile, extracellular ATP (eATP) is known to induce the production of SASP factors, but the relationship between eATP and natural ageing is unknown. In this study, we showed the relationship between the increase of eATP in the epidermis and the dermal thinning seen with natural ageing. Peppermint leaf extract (PME) effectively suppressed the rise in eATP concentration due to natural ageing and environmental stress. Furthermore, PME suppressed skin thinning and improved various wrinkles, such as crow’s feet and neck wrinkles. These results suggest that PME is an antiageing material that suppresses eATPmediated dermal thinning and effective