Why does the industry need a new model to predict mildness to skin? In this article we will cover what the existing methods are and what their limitations might be, and also how we worked on those and optimised those to create a new model. The correlation between in vitro testing for skin irritation and in vivo testing for skin irritation. At the end of the article we will also offer some real world applications.
To address the first question of why we need to have a new method to predict skin mildness it is important to realise there is clearly an increasing demand from consumers for milder and milder products. In line with that, companies are finding that there is an increasing demand to substantiate marketing claims that are going to differentiate them from the rest of the market. In addition, existing animal data is used to validate in vitromethods on a regular basis. That is the gold standard. What we wanted to do instead was to move away from that quite archaic approach and to make sure that we could validate our in vitromethods against real human data which is much more scientifically relevant to the cosmetics of today
XCellR8 embarked on a research project together with Cutest with funding from Innovate UK. The aims of the work were to firstly optimise in vitroand in vivotest methods, to make sure that they were sensitive enough to detect very subtle differences between mild formulations, and then to assess the predictive capacity of those tests.
Existing methods
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