As we age, the production of collagen and elastin is reduced, which results in sagging skin that can most notably be observed at the face contours of the jawline. Mesenchymal stem cells have been shown to improve collagen production and regenerate the skin, for example during wound healing.
These processes are mediated by vesicles known as exosomes which are produced and secreted by these stem cells. A novel active ingredient based on goji plant stem cells was shown to improve the stemness of aged mesenchymal stem cells as well as increase exosome signalling by mesenchymal stem cells, which in turn improves extracellular matrix production in fibroblasts. The improved extracellular matrix rejuvenates the skin by improving skin density, reducing wrinkles and reshaping the face for an improved V-shape of the face..
Mesenchymal stem cells (MSCs) reside in many different tissues, including the subdermal adipose tissue. They are multipotent precursors of many different cell types, although they are morphologically and characteristically highly similar to fibroblasts.1 Interestingly, MSCs were shown to improve and accelerate various regeneration processes such as cutaneous wound healing. Even more notably, it has been shown that mainly the MSCs themselves are not needed for this process but rather a cell-to-cell signalling mechanism deriving from MSCs that promotes proliferation, migration and collagen production of dermal fibroblasts. This beneficial signalling from MSCs to fibroblasts has recently been shown to occur through vesicles called exosomes.2-4
Cell-to-cell communication via exosomes
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