The epidermis is one of the most active tissues in terms of regeneration thanks to the ability of the stem cells from the basal layer to divide and renew themselves. With age, this regenerative potential and the overall function of epidermis are reduced resulting in the development of ageing signs, such as appearance of wrinkles and loss of radiance.
Lipotec’s latest development, Reproage peptide, may induce cellular reprogramming in the epidermal basal layer through the modulation of epigenetic elements, which can help reactivate basal cells and their regenerative abilities, leading to an improved appearance of mature skin.
Specifically, the microRNA145 is an epigenetic regulator known to repress the activity of the stem cell transcription factors, restraining the stemness properties of the basal cells. The new peptide reduces the levels of microRNA-145 and increases the level of the stem cell factors related to stemness, contributing to an improvement in the skin properties
Twoin vivoassays, performed using 2% peptide solution twice a day during 56 days, showed a general improvementin skin complexion and more radiance with 1.5% increase in luminance as well as a rejuvenated skin with epidermal self-renewal activity increased to the level of a skin 17 years younger in the 50-55 years old volunteers and up to 41.3% decrease in skin roughness.
Reproage peptide assists in obtaining a smoother, more radiant and visually rejuvenated complexion and can be incorporated into any anti-ageing formulation to cope with the slowdown in skin regeneration that takes place with age or in products designed to rejuvenate the skin.
