DSM has developed a comprehensive approach to protect skin against the effects of environmental stressors, which the company is calling ‘Five Actives – Five Actions’. The approach has built on recent scientific advances to determine how the company’s leading actives can be applied to improve skin comfort, protection, colour, quality, and perfection.
DSM’s Personal Care business unit reveals a comprehensive new evidencebased concept that combines five leading DSM actives: Alpaflor Edelweiss, PEPHATight, PEPHA-Protect, REGUFade and Preregen PF. With their known mode of action and provenin vivoefficacy on skin appearance and sensation, these were the ideal candidates to generate anti-pollution actives.
For the ‘Five Actives – Five Actions’ approach newin vitro studies were conducted on the pollutants urban dust (PM 2.5 & PM 10), benz(a)pyrene (BaP, a pollutant found in industrial combustion processes, car exhausts and cigarette smoke), and ozone. Focus parameters were oxidative damage, skin barrier disruption, cell viability reduction, inflammation induction, and epigenetic modulation.
Results clearly showed that the ‘Five Actives – Five Actions’ approach helps to increase cell viability, to reduce inflammation markers IL-8 and PGE2, to modulate epigenetic marker microRNA and to reduce DNA damage. Ultimately the research distinguished five actions leading to improved skin comfort, protection, colour, quality, and perfection.
