DSM has shared new research findings confirming extra efficacy on skin by ReguScence, a pure white asparagus extract from the Navarra region.
The molecule, launched by DSM in 2014, proved to be highly effective in antiageing applications. Thanks to its mechanism of action it delays the cellular ageing process by stimulating the skin’s own autophagy capabilities.
The findings, in a pair of published studies by Murase et al and De Mazière et al, as well as new DSM in vitro data, suggest that the autophagy process plays a key role in melanogenesis. Several proteins, such as Melan-A and Pmel-17, are involved in early melanosome formation. Stimulation of the autophagy pathway leads to increased synthesis of lysosomes, which are capable of degrading these proteins, leading to a reduction of melanosomes, and ultimately, a more even skin tone.
Recent scientific tests on pigmented epidermis equivalents conducted by DSM indicates the efficacy of Regu-Scence at 3% to enhance the appearance of a more even skin tone. In vitro, this ingredient has shown a significant down-regulation of tyrosinase marker by up to 65% and of the recently discovered Melan-A marker by up to 30% in a 9-day test.
