Mibelle Biochemistry won the BSB Innovation Prize at in-cosmetics 2015 with its PerfectionPeptide P7 ingredient. PerfectionPeptide P7 is a biologically active heptapeptide that stimulates the skin’s own self-defense mechanisms against oxidative stress at the cellular level.
Our cells respond to oxidative stress by activating the transcription factor Nrf2. This is a master switch in the cellular self-protection system that leads to an increased synthesis of cell protecting enzymes in order to fight oxidants, free radicals and toxins. However, this self-protection system of the skin is unable to cope with an excess of stress factors and it also declines with age.
Normally Nrf2 activity is repressed by the Keap1 protein. Nrf2 only becomes activated when the cells are faced with too much oxidative stress. In response to this, Mibelle Biochemistry has designed a heptapeptide that is a competitive inhibitor of the Keap1 repression. Consequently, Nrf2 is now constantly present in its active form and arms the skin cells for challenges from any stress caused by oxidants or other reactive chemical species.
In cell culture assays, PerfectionPeptide P7 clearly stimulated the expression of detoxifying enzymes. In ex vivo experiments and clinical trials the peptide has shown an ability to significantly protect the skin from oxidative stress at the cellular level by significantly reducing DNA Damage, the formation of sunburn cells as well as the depletion of Langerhans cells.
To ensure the stability and bioavailability of PerfectionPeptide P7 the peptide has been encapsulated into a novel soft sphere carrier system that is based on shea butter.
PerfectionPeptide P7 is much more than an antioxidant: it offers a 360° protection from daily stress factors, ROS and toxins.
