Marc Heidl Ph.D. – Pentapharm, Switzerland
Mimic wrinkles are part of the visible face wrinkles. As time passes, these wrinkles persist permanently and become deeper and deeper: frown lines, laughter lines and crow’s feet appear more and more due to the repeated movements of facial muscles.
Acting at the post-synaptic membrane, SYN-AKE is a reversible antagonist of the muscular nicotinic acetylcholine receptor (mnAChR). We assume that the tripeptide is binding to the epsilon subunit of the mnAChR which prevents binding of acetylcholine to the receptor – consequently it remains closed. In the closed state, there is no uptake of sodium ions (Na+), so that no depolarisation takes place, and the muscles stay relaxed (Fig. 1).
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Analysis of the primary structure of Waglerin-1 shows a frequent pattern of a positively charged amino acid near a proline residue, and two patterns with two positively charged amino acid separated by a proline residue.
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