A new proof of the efficiency of Matrixyl 3000, the well-known matrikine based anti-ageing ingredient from Sederma, is available. This time, its ability to help repair the UV damage-prone papillary dermis has been demonstrated.
The papillary dermis, located just under the dermis/epidermis junction (DEJ), is more fragile than the reticular dermis and is intensely affected by photo-ageing. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing, and that is why papillary dermis repair delivers visible antiwrinkle benefits. In vivo studies have revealed the positive matrix reinforcing effect of Matrixyl 3000 by measuring the SLEB density (Subepidermal Low Echogenic Band that corresponds to the papillary dermis). A significant improvement corresponding to a gain in age of 1.8 years is visible in just one month, and confirmed after two months: the photo-induced ageing is then delayed by 5.5 years. Another analysis of the papillary dermis by confocal laser microscopy has shown that Matrixyl 3000 helps reduce the fibre fragmentation and notably supports the reconstruction of the papillary dermal fibre network. This new test confirms the repairing effects of Matrixyl 3000: promotion of wrinkle smoothing and improvement of skin tone and elasticity.
