Multifunctional properties of euphorbiaceae plants

The study was carried out using DPPH scavenging activity method according to Shimada et al for oxidation agent. We also conducted the dermatological safety test using Repeated Opened Patch Test (ROPT) and Single Closed Patch Test (SCPT), where each test involved more than 50 selected healthy volunteers who signed informed consent. The in vitro testing showed that JE and EE* at the concentration of 1%, 3% and 5% had low to high DPPH scavenging activity and its potency as compared to ascorbic acid was in range 46.3% – 89.9%. From the ROPT, it was shown that JE and EE* did not cause any irritation or allergic skin reaction. From SCPT, at the concentration 5% JE and EE* could cause irritation and allergic skin reaction but still within allowable range (not more than 3.8% of all subjects). The HETCAM test showed that the ocular irritation caused by JE and EE* were also within acceptable range. The efficacy study on moisture content showed that JE and EE* could significantly increase the skin moisture content. These results indicate that JE and EE* are safe for human skin as well as for eyes, and can be used as a natural antioxidant and moisturising agent which also maintains the skin barrier. Note: *= patent pending

 The demand for naturally derived active ingredients for cosmetics continues to increase in Indonesia. With its large biodiversity, the country provides us with the opportunity to tap for natural active ingredients. The objective here is to explore the active ingredients from several Indonesian plants. Several aspects should be considered when utilising plant materials in cosmetics, such as, the quality of the natural raw materials, process, biological activity, and safety considerations. The objective of this study is to explore the active ingredients from several Indonesian plants, which have antioxidant and moisturising activity.

Materials