At our poster session, we presented our research on the circadian rhythm of skin and Glucosyl Naringin (GN), an upcycled personal care ingredient. We discovered that GN protects the epidermal barrier by repairing the damage caused by oxidative stress, a major environmental factor.
GN is a glycosylated citrus polyphenol scientifically proven to improve skin elasticity by promoting both the quality and quantity of elastin, making it a beneficial ingredient for anti-aging products. (Learn more about Glucosyl Naringin)
The circadian rhythm of skin is known to regulate multiple physiological functions such as skin barrier repair and water retention. Its disruption may result in decreased skin barrier function and degradation of the basement membrane, leading to skin aging effects such as dryness, rough skin, wrinkles, and sagging. Our internal clock can be easily disrupted by lifestyle changes and daily stress as the genes regulating the skin barrier and inflammation are controlled by the clock genes.
Building on this background, we conducted further evaluation to explore the relationship between GN and circadian rhythm. We measured the expression of circadian clock, skin barrier and inflammatory related genes throughout the day, introducing the exposure of oxidative stress to cause disturbances.
It is known that the skin barrier and inflammation related gene expression follows circadian rhythm. The Nagase Viita research team succeeded in observing the disturbance of circadian rhythm caused by oxidative stress, which is new to report.
Furthermore, we found that GN restores oxidative stress disrupted circadian rhythm to its original rhythm and contributes to the recovery of stress induced epidermal barrier damages.
From these findings, the topical application GN can help restore the circadian rhythm of the skin barrier, reduce inflammation, and prevent skin aging.
Awaken your skin’s natural power by Glucosyl Naringin.
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