Mibelle Biochemistry describes an active ingredient derived from Chios mandarins markedly increases the firmness and density of the skin. This upcycled ingredient is based on the peel paste of organic mandarins discarded from the distillation process of fragrance production
ABSTRACT
‘Inflammaging’, a term coined by Professor Franceschi two decades ago, refers to a persistent, low-grade inflammatory state that develops with age due to a combination of chronological ageing, intrinsic factors, and external stressors. As we age, the body’s capacity to counter inflammation diminishes, leading to this chronic inflammatory state, which contributes to visible signs of ageing skin and age-related pathologies, creating a vicious cycle. In fact, this inflammatory state reduces the energy available to produce essential skin molecules like hyaluronic acid and collagen, levels of which are observed to decrease in ageing skin. Therefore, boosting energy to enhance the production of these vital molecules can significantly benefit the skin.
Both intrinsic and extrinsic stressors contribute to inflammation and accelerate the ageing process by generating reactive oxygen species (ROS).1 ROS activate the transcription factor NF-κB, which translocates into the nucleus upon activation, and in turn triggers the transcription of various proinflammatory genes, including some encoding cytokines, chemokines, and matrix metalloproteinases (MMPs).2
Log in or register FREE to read the rest
This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text.
If you don't already have an account, please register with us completely free of charge.
