Nagase Viita will present new insight to improve circadian rhythm disruptions by its Glucosyl Naringin (GN) ingredient at the 2024 International Federation of Societies of Cosmetic Chemists (IFSCC) Congress in Brazil.
At the poster session during the event on 15-17 October at Iguazu Falls, the company will showcase the relationship between skin circadian rhythm and GN, an upcycled personal care ingredient that is a glycosylated citrus polyphenol.
Naringin, the aglycon of GN, is known to possess useful physiological functions such as anti-inflammatory and antioxidant effects.
However, its extremely low solubility has long hindered its use in personal care products.
By combining glucose and Naringin with Nagase Viita’s proprietary enzyme technology, its water solubility increased by more than 6,000 times compared to naringin.
GN is scientifically proven to improve skin elasticity, making it beneficial for anti-ageing products.
To further evaluate GN’ effects on skin, Nagase Viita examined the relationship between GN and circadian rhythm, the body’s biological clock.
Recent dermatological science revealed that circadian rhythm affects not only sleep patterns but also regulates multiple physiological functions such as skin barrier repair and water retention.
It is also known that disruptions to skin circadian rhythm due to lifestyle changes and daily stress can lead to skin dryness and roughness.
These findings inspired personal care companies to create skincare products tailored for morning and night use: daytime products aim to minimize stress and external disturbances, while nighttime products focus on nourishing and repairing the skin during sleep.
In this study, Nagase Viita investigated how GN alters the expression of clock genes and other related genes, discovering that it improves circadian rhythm disturbances caused by oxidative stress in epidermal keratinocytes.
