Givaudan tackles ‘OxInflammation’ with Silybidiol

Givaudan Active Beauty has unveiled Silybidiol, said to be the first globally compliant alternative to the iconic CBD (cannabidiol) molecule.

Designed to combat the harmful effects of urban photo-pollution and promote skin health, Silybidiol is extracted from the fruit of the milk thistle with green fractionation.

Givaudan says it offers a new, holistic approach to ageing, leveraging the emerging concept of ‘OxInflammation’, the vicious cycle connecting oxidative stress and inflammation.

In recent years, the perception of skin care and ageing has evolved towards a more positive and resilient approach known as "pre-ageing".

This approach emphasises the importance of self-care, focusing on prevention and overall wellbeing.

It recognises the link between positive emotional wellbeing and skin condition, promoting skin health and longevity. The exposome - the set of extrinsic aggressors to which our skin is exposed - is an important factor challenging skin health and longevity.

It encompasses UV radiation and pollution, which disrupt the skin’s delicate

‘OxInflammation’ balance - the interconnection of two key biological pathways. These factors can have a damaging cumulative effect on skin health and emotional balance.

Silybidiol binds to cannabinoid receptors in the skin and activates cellular crosstalk leading to the activation of skin defences and detoxification pathways to effectively maintain 'OxInflammation' balance and promote wellbeing.

Clinically tested versus placebo and CBD, on volunteers exposed to photo-pollution, Silybidiol is claimed to offer: a drastic improvement in skin homogeneity (2.7x better than CBD), enhanced skin radiance (1.6x better than CBD); and an improvement in volunteers’ wellbeing (equivalent to CBD).

“We discovered that Silybidiol specifically activates CB2 cannabinoid receptors and delivers the same benefits as the hero CBD molecule,” said R&D director Romain Reynaud.

“As such, not only does it reduce inflammation, which improves skin tone, but it also stimulates the production of beta-endorphins, feel-good peptides that contribute to overall wellness,” he added.

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