Acne vulgaris is a common chronic skin disease affecting individuals of all ages. The pathogenesis of acne is characterized by four core events: hyperseborrhoea, epithelial hyperkeratinization, Cutibacterium acnes colonization and inflammation.1 Due to the multifactorial nature of the disease, a combination therapy or use of multifunctional compounds are the preferred approaches.
Retinoids are among the most effective compounds targeting multiple acne-associated pathways.1 However, they often cause negative adverse effects including skin dryness and irritation.1
Therefore, there is still a need for new, more effective and safer alternatives. In this study, we evaluated a new hexapeptide in complex with zinc (Zn-peptide) for its ability to inhibit the key acne-related processes in vitro and to improve the appearance of the acne-prone skin in vivo. The effects were compared to its individual components and retinol as the most popular retinoid used in cosmetics.
Materials and methods
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