The website of Personal Care Global

3D modelling of Malassezia furfur skin interaction

Straticell illustrates in a 3D model that Malassezia furfur invades the upper layers of the reconstructed epidermis with deleterious impacts on the barrier function, inducing an effective immune and inflammatory response, at both gene and protein levels

Malassezia furfur is a lipid-dependent yeast naturally living on the skin. Despite its tolerance by the immune system under healthy condition, M. furfur overgrowth is associated with skin disorders such as dandruff. 

Dandruff and its more severe form seborrheic dermatitis (SD), are common chronic inflammatory conditions characterized by an abnormal shedding of the skin in seborrheic areas of the body. While dandruff is restricted to the scalp, SD also affects oily rich areas of the face, causing itching, pruritic lesions and erythema

Environmental and internal stress factors, dysregulation of the immune system and fungal colonization are amongst the main contributors to the development of SD and dandruff.1 It has been described that in dandruff, the quantity of Malassezia can increase up to 1.5 to 2 times its normal level.2

Log in or register FREE to read the rest

This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text. If you don't already have an account, please register with us completely free of charge.
Register

Upcoming Events

8th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
29 - 30 November 2022

76th Annual Scientific Meeting & Showcase

JW Marriott LA Live, Los Angeles, California
12 - 14 December 2022

PCHi China 2023

The China Import and Export Fair Complex, Guangzhou
15-17 February 2023

in-cosmetics Global 2023 - Barcelona

Fira Barcelona Gran Via
28 - 30 March 2023

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

Upcoming Events

8th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
29 - 30 November 2022

76th Annual Scientific Meeting & Showcase

JW Marriott LA Live, Los Angeles, California
12 - 14 December 2022

PCHi China 2023

The China Import and Export Fair Complex, Guangzhou
15-17 February 2023

in-cosmetics Global 2023 - Barcelona

Fira Barcelona Gran Via
28 - 30 March 2023

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

Step Communications Ltd, Step House, North Farm Road, Tunbridge Wells, Kent TN2 3DR
Tel: 01892 779999 Fax: 01892 616177
www.step-communications.com
© 2022 Step Communications Ltd. Registered in England. Registration Number 3893025