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3D skin model to study bacteria-host interactions

Straticell, a Belgian provider of in vitro efficacy testing for dermato-cosmetic products, explains how it has developed a new 3D model to study the interactions between the skin and its flora, by colonizing reconstructed human epidermis with microorganisms of interest

While it was long thought that acne was due to the presence of a bacterium named at this time Propionibacterium acnes, it is now admitted that the development of acne spots is related to an imbalance in the phylotypes (phylogenetically related individuals) of this bacterium now renamed Cutibacterium acnes.  

The pathophysiology of acne is indeed the result of an increase in the IA1 phylotype of C. acnes, in sebum-rich areas.1 The hyperseborrhea combined to the hyperkeratinization form a lipid-rich anaerobic environment that favours the growth of C. acnes. 2

Additionally, acne-prone skins also display an overexpression of genes encoding proinfl ammatory molecules such as interleukin 8 (IL-8, encoded by the CXCL-8 gene) and interleukin 1 beta (IL-1β, encoded by the IL1B gene), as well as antimicrobial peptides like the human β-defensin 2 (hBD2, encoded by the DEFB4 gene).2,3

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Upcoming Events

PCHi China 2023

The China Import and Export Fair Complex, Guangzhou
15-17 February 2023

SCSS - Conference & Laboratory Workshop

Republic Polytechnic - Woodlands Ave 9, Singapore 738964
Thur 16th & Fri 17th March 2023

in-cosmetics Global 2023 - Barcelona

Fira Barcelona Gran Via
28 - 30 March 2023

NYSCC Suppliers' Day 2023

Javits Center, New York
2 - 3 May 2023

CITE Japan 2023

Pacifico Yokohama, Japan
17 - 19 May 2023

in-cosmetics Korea 2023

Hall C, Coex, Seoul, South Korea
12 - 14 July 2023

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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