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Senolytics: Eliminating senescent cells

Alpine Rose Active, an organic purified extract of the leaves from an iconic Swiss flower eveloped by Mibelle Biochemistry, can protect and rejuvenate the skin through senolytic activity and has similar benefits for the scalp

ABSRACT

Cellular senescence, a condition of irreversible cell cycle arrest, can lead to inflammation and accelerated ageing of tissues, including the skin. To prevent this, current strategies aim specifically to eliminate the senescent cells, or ‘zombie cells’, by means of senolytics. Sensitive scalps are a prominent problem and one potential treatment option is the use of senolytics in scalp care. As with the skin, zombie cells in the scalp can cause local inflammation, leading to dry and irritated scalps, so clearing these cells could promote a healthy scalp. An extract from the leaves of the Swiss Alpine rose was found to have strong senolytic activity in fibroblasts. In a placebo-controlled clinical study, the extract further demonstrated a significant soothing effect on sensitive scalps. This study firstly highlights the positive impact of senolytics in scalp health and care.

One of the hallmarks of ageing is the accumulation of senescent cells.1 Cellular senescence is a condition of irreversible cell cycle arrest, where the cells do not proliferate anymore, but are still viable and therefore ‘not quite dead yet’. This led to them being characterised as ‘zombie cells’. Importantly, senescent cells show an increased secretion of numerous different factors, such as matrix metalloproteinases, chemokines and inflammatory cytokines, which are termed senescence-associated secretory phenotypes (SASP).2

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Upcoming Events

PCHi

Shanghai World Expo Exhibition And Convention Center(SWEECC)
20th-22nd March 2024

in-cosmetics Global

Paris Expo Porte de Versailles
16th – 18th April 2024

NYSCC Suppliers' Day 2024

Javits Center, New York
1st - 2nd May 2024

9th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
25th - 26th June 2024

in-cosmetics Korea 2024

Hall C, Coex, Seoul, South Korea
24th - 26th July 2024

in-cosmetics Latin America 2024

São Paulo, Brazil
25th - 26th September 2024

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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