Malassezia furfur is a lipophilic and dermatological pathogenic yeast, which normally exists on human skin, and causes tinea versicolor, seborrhoeic dermatitis, and atopic dermatitis, especially on human scalp. The multi-herb extraction, VGP, which consists of Vitex trifolia fruit, Gentiana scabra, and Polygonum multiflorum root extract was used to study its effect of anti-inflammation, controlling sebum and dandruff on scalp care. Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur, VGP can inhibit the expression of interleukin 6 (IL-6), prostaglandin E2 (PGE-2), monocyte chemoattractant protein 1 (MCP-1) and interleukin 1β (IL-1β) in a dose-dependent manner under 0.01% to 0.125% concentration. On the inflammatory model of 3D reconstructed skin induced by H2O2, VGP significantly improved the cell viability and skin structure, and reduced the production of interleukin 8 (IL-8), PGE-2, and leukotriene B4 (LTB4). During 4 week&rsq
Scalp care efficacy of a multi-herb extract
Caring for the scalp is very much in focus currently. Greaf present their complex of natural extracts to help maintain a healthy scalp for healthy hair
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