Encapsulated CBD and pine extract for relaxed skin

To contribute to this trend, a nanoemulsion of CBD encapsulated with organic hemp seed oil was combined with an extract of Swiss stone pine to yield a potent cosmetic active ingredient. This phyto-complex possesses an improved water solubility and bioavailability compared to CBD alone. The complementary effect of the CBD/Pine extract mixture on reducing inflammation signalling and improving skin regeneration processes was demonstrated in vitro. In a placebo-controlled clinical study, the CBD/Pine extract improved the skin tone and texture, reduced wrinkles and improved facial shape due to its “skin relaxing” effect

n the past couple of years, food, beverage and personal care products containing cannabidiol (CBD) quickly rose in popularity and the market continues to grow rapidly. CBD has become a trend ingredient in skin care and, more recently, in hair care as well. Unlike tetrahydrocannabinol (THC), another cannabinoid found in the Cannabis sativa plant, CBD is non-psychoactive and can potentially even reverse the psychotic effects of THC. 1 CBD additionally provides numerous health benefits. For example, in 2018 the FDA approved the first prescription drug based on CBD for the treatment of epileptic seizures. 2 Furthermore, ingestion or inhalation of CBD is used to treat anxiety, insomnia and for chronic pain relief with around 200 clinical studies planned or completed to date. 3

In contrast, the effects of topical CBD application have not been as extensively studied and all its interactions and mechanisms in the skin have not yet been unravelled. However, the involvement of CBD in some biochemical pathways in the skin have previously been demonstrated (Fig 1). Notably, CBD does not have a strong affinity for the cannabinoid receptors CB1 and CB2, which are part of the endocannabinoid system of our body. 4 Instead, CBD can interact with and desensitise TRPV1, a pain receptor that is expressed in nerve fibres as well as in keratinocytes and endothelial cells. 5 CBD was shown in UV-irradiated keratinocytes to increase the activity of antioxidant enzymes, by stimulating the transcription factor NRF2 as well as inhibiting the pro-inflammatory transcription factor NFkB. 5 Topical application of CBD was shown to increase epidermal thickness as well as the expression of cytokeratins KRT16 and KRT17, which are associated with keratinocyte proliferation and wound repair. 6 CBD is therefore able to soothe and protect the skin, reduce inflammation as well as improve wound healing