During this process the skin cells become senescent, they slow down their metabolism and the production of structural matrix components. The Growth Differentiation Factor 11 (GDF11) has been recently identified as a pro-youth factor in several cell types, and in particular it was shown its involvement in the restoration of a young phenotype in skin fibroblasts, by stimulating important ExtraCellular Matrix proteins. Furthermore, its key role in modulating mitochondrial functions in skin cells during ageing has been highlighted. In the present article, we describe the characterisation of a plant extract, obtained from Rosa rugosatissue cultures, able to produce a ‘rejuvenating’ effect in aged skin fibroblasts by inducing GDF11 expression and synthesis. The extract was also capable of increasing the expression of PGC1alpha, the master regulator of the mitochondrial biogenesis, and other important genes involved in the pathway, leading to an improvement of cell metabolism a
New ingredient from Rosa rugosa delays skin ageing
Skin ageing is an inevitable physiological process, determined by several concomitant factors, resulting in a thinner and drier skin, in the formation of fine wrinkles, and a gradual dermal atrophy.
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