Firstly, the aim of this study was the characterization of the skin microbiota with a focus on Cutibacterium acnes(C. acnes) phylotypes in subjects with acne. Secondly, microbiota changes after 28 days’ treatment of berries, Rhodomyrtus tomentosaactive ingredient (RT), rich in acylphloroglucinols, polyphenols, and organic acids were analyzed. Clinical evaluations (lesion counts) were performed at baseline (D0) and after 28 days (D28) of twice-daily application of RT active ingredient.
Acne is one of the most common skin diseases worldwide affecting up to 85% of the population.1 At the pathophysiological level, two factors play a crucial role: the sebaceous gland and Cutibacterium acnes. More precisely, located in the sebaceous gland-rich sites of skin,C. acnesis a grampositive aero-tolerant anaerobic bacterium belonging to the Actinobacteriaphylum. Several mechanisms have been proposed by which C. acnesaggravates acne, including augmentation of lipogenesis, comedone
