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Autophagy as a new strategy to reduce pigmentation

Regulation of skin function and preservation of skin health are major targets in cosmetics. To achieve these goals, several strategies have been used i.e. activating cell signalling pathways, acting on epigenetic regulations, physically blocking external stresses... Among them, regulating autophagy appears a promising one.

Autophagy is a cellular mechanism which preserves cell health by recycling long-lived proteins and damaged organelles. This catabolic pathway starts with the sequestration of the targeted organelles subject to degradation along with a portion of cytosol into a double- or multi-membrane structure known as phagophore. This structure elongates after closure to form a vesicular structure, termed autophagosome. Subsequently, the mature autophagosome fuses with the lysosome, thereby forming a single membrane structure (autolysosome) where protein degradation is promoted by lysosomal enzymes 1,2 Autophagy constitutively occurs at basal cellular level to ensure the homeostatic turnover of cell components but can also be activated when the cells need to clear potentially toxic cytoplasmic materials or when the cells are under various stress conditions like oxidative stress3 or radiation.4,5 Under these circumstances, altered components are degraded to be subsequently replaced by newly produc

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Upcoming Events

in-cosmetics Korea 2022

Hall C, Coex, Seoul, South Korea
13 - 15 July 2022

SCSS Suppliers Day - SINGAPORE

SINGAPORE MARRIOTT TANG PLAZA HOTEL
Thursday 25th & Friday 26th August 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Latin America 2022

Expo Center Norte, Sao Paulo
21 - 22 September

Cosmetorium 2022

Palau de Congressos de Barcelona
28 - 29 September

SEPAWA 2022

Estrel Congress Center, Berlin
26 - 28 October

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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