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Using autophagy to prevent and reduce skin ageing

Autophagy is a cellular mechanism which preserves cell health by recycling long-lived proteins and damaged organelles.

 With the discovery of its mechanisms by Professor Yoshinori Ohsumi (Nobel Prize in Physiology and Medicine 2016), autophagy has been the subject of intense research interest that revealed its role in various physiological and pathological conditions. 

This catabolic pathway consists of multiple sequential steps, promoted through two well-characterised signalling cascades known as mTOR (mammalian Target Of Rapamycin)-dependent and mTOR independent pathways. The process starts with the sequestration of the targeted organelles subject to degradation along with a portion of cytosol into a double-or multimembrane structure known as phagophore. This structure elongates after closure to form a vesicular structure, termed autophagosome. Subsequently, the mature autophagosome fuses with the lysosome, thereby forming a single membrane structure (autolysosome) where protein degradation is promoted by lysosomal enzymes.1,2 

Autophagy constitutively occurs at basal cellular level to ensure the homeostatic turnover of cell components but can also be activated in the following conditions: (i) when the cells need to mobilise intracellular nutrients, (ii) when the cells need to clear potentially toxic cytoplasmic materials or (iii) when the cells are under various stress conditions like oxidative stress or radiation.3 Under these circumstances, altered components are degraded to be subsequently replaced by newly produced ones, allowing the cells and organisms to preserve their physiological functions. 

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Upcoming Events

SCSS Suppliers Day - SINGAPORE

SINGAPORE MARRIOTT TANG PLAZA HOTEL
Thursday 25th & Friday 26th August 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Latin America 2022

Expo Center Norte, Sao Paulo
21 - 22 September

Cosmetorium 2022

Palau de Congressos de Barcelona
28 - 29 September

SEPAWA 2022

Estrel Congress Center, Berlin
26 - 28 October

in-cosmetics Asia 2022

BITEC Bangkok, Thailand
1 - 3 November 2022

Access the latest issue of Personal Care Global on your mobile device together with an archive of back issues.

Download the FREE Personal Care Global app from your device's App store

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