The website of Personal Care Global

Deuterium isotope labelling of colloidal mixtures

Deuteration is the process in which all or some of the hydrogen (1H or H) atoms of a compound are replaced by the stable (nonradioactive) heavier isotope of hydrogen, deuterium (2H or D). Different isotopes of the same element exhibit nearly identical chemical behaviour.

This makes deuterated and protonated compounds almost identical in chemical properties, however they still differ in some physical and nuclear properties which make them useful in a number of characterisation techniques. For example, neutrons interact with (and scatter from) nuclei, rather than with electrons, which makes neutrons extremely sensitive to the difference between the hydrogen atom and its deuterium isotope, since the mass difference between the two nuclei is so pronounced. In biological systems which are typically rich in hydrogen, selective substitution of hydrogen with deuterium can therefore be used to create contrast and highlight the position, structure, interactions or dynamics of individual components within complex macromolecular systems or assemblies. This is particularly useful in applications using small-angle neutron scattering, neutron reflectometry, neutron protein crystallography and neutron spectroscopy. Deuteration is not limited to neutron studies but is also effective in conjunction with nuclear magnetic resonance (NMR) and vibrational spectroscopies, which are used to study the structure and function of synthetic polymers or other nanotechnology or biotechnology-relevant materials. 

In addition to its use as a characterisation tool, deuteration has been used to enhance the properties of end-use products. For example, the kinetic isotope effect has been recognised broadly, to improve the metabolic fate of numerous drug and healthcare entities. A nonexhaustive list of deuteration applications in this area is summarised below.

The diversity of techniques that benefit from deuteration inspired the Australian Nuclear Science and Technology Organisation (ANSTO) to build capability in the biological applications of deuteration to neutron and X-ray scattering in 2002. This positioned ANSTO as the only experienced player when, in 2006, the Australian Government’s National Collaborative Research Infrastructure Strategy (NCRIS) identified the need for a national deuteration facility to meet demand from the Australian research community. The NCRIS scheme allowed ANSTO to expand its scope to include not only biological deuteration but also chemical deuteration. 

Log in or register FREE to read the rest

This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text. If you don't already have an account, please register with us completely free of charge.
Register

Upcoming Events

SCSS Suppliers Day - SINGAPORE

SINGAPORE MARRIOTT TANG PLAZA HOTEL
Thursday 25th & Friday 26th August 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Latin America 2022

Expo Center Norte, Sao Paulo
21 - 22 September

Cosmetorium 2022

Palau de Congressos de Barcelona
28 - 29 September

SEPAWA 2022

Estrel Congress Center, Berlin
26 - 28 October

in-cosmetics Asia 2022

BITEC Bangkok, Thailand
1 - 3 November 2022

Access the latest issue of Personal Care Global on your mobile device together with an archive of back issues.

Download the FREE Personal Care Global app from your device's App store

Upcoming Events

SCSS Suppliers Day - SINGAPORE

SINGAPORE MARRIOTT TANG PLAZA HOTEL
Thursday 25th & Friday 26th August 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Latin America 2022

Expo Center Norte, Sao Paulo
21 - 22 September

Cosmetorium 2022

Palau de Congressos de Barcelona
28 - 29 September

SEPAWA 2022

Estrel Congress Center, Berlin
26 - 28 October

in-cosmetics Asia 2022

BITEC Bangkok, Thailand
1 - 3 November 2022

Access the latest issue of Personal Care Global on your mobile device together with an archive of back issues.

Download the FREE Personal Care Global app from your device's App store

Step Communications Ltd, Step House, North Farm Road, Tunbridge Wells, Kent TN2 3DR
Tel: 01892 779999 Fax: 01892 616177
www.step-communications.com
© 2022 Step Communications Ltd. Registered in England. Registration Number 3893025