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What is new in acne?

Acne vulgarisis a multifactorial skin disease, and its pathogenesis includes increased sebum production (hyperseborrhea), hyperkeratosis, proliferation of Cutibacterium acnes(C. acnes) and inflammation.

 In particular, sebum overproduction is a major concurrent event in the development of acne lesions because sebum serves as a nutrient source for C. acnes, activating toll-like receptors TLR2 and TLR4, leading to the release of proinflammatory cytokines/chemokines such as interleukin-1α(IL-1α), IL-6, IL-8, tumour necrosis factor-α (TNF-α), and adhesion molecule like intercellular adhesion molecule-1. It can also promote hyperkeratinisation, resulting from abnormal keratinisation of infundibular epithelium. Therefore, developing novel cosmetic active for acne, by targeting a diverse range of pathological factors is of particular importance. Pronounced properties of Rhodomyrtus tomentosathrough the molecules of interest it contains suggest a path towards developing a novel anti-acne agent. This is the method that Greentech used.

Acne vulgarisis an inflammatory and multifactorial skin disease1affecting more than 85% of adolescents and often continuing into adulthood.2The majority of epidemiologic studies of acne have focused on adolescents. Those who have studied adult acne reported a higher prevalence of acne among male patients before the age of 16 years, but a higher prevalence among female patients after the age of 23 years. The overall prevalence of acne does decline with age in both sexes, but it is clear that a significant number of individuals experience either a worsening of acne symptoms or fail to experience improvement after the teenaged years. 

Moreover, although most epidemiological data in Western countries concern Caucasian skin types, acne is also a significant problem for Asian skin. In fact, in one large intercontinental epidemiological study among women, the prevalence of clinical acne was reported to be similar between geographical zones, 24% in Caucasian, 30% in Asian and 23% in continental Indian women. However, acne type was found to vary between skin subtypes. Asian women were reported to have a higher prevalence of infammatory acne than comedonal acne (20% vs 10%), compared to Caucasian women, for whom comedonal acne was more prevalent (14%) than infammatory acne (10%).3 

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Upcoming Events

in-cosmetics Global

Paris Expo Porte de Versailles
16th – 18th April 2024

NYSCC Suppliers' Day 2024

Javits Center, New York
1st - 2nd May 2024

9th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
25th - 26th June 2024

in-cosmetics Korea 2024

Hall C, Coex, Seoul, South Korea
24th - 26th July 2024

in-cosmetics Latin America 2024

São Paulo, Brazil
25th - 26th September 2024

IFSCC 2024

Recanto das Cataratas Thermas Resort, Iguazu Falls, Brazil
14th - 17th October 2024

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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