Acne vulgarisis a multifactorial skin disease, and its pathogenesis includes increased sebum production (hyperseborrhea), hyperkeratosis, proliferation of Cutibacterium acnes(C. acnes) and inflammation.
In particular, sebum overproduction is a major concurrent event in the development of acne lesions because sebum serves as a nutrient source for C. acnes, activating toll-like receptors TLR2 and TLR4, leading to the release of proinflammatory cytokines/chemokines such as interleukin-1α(IL-1α), IL-6, IL-8, tumour necrosis factor-α (TNF-α), and adhesion molecule like intercellular adhesion molecule-1. It can also promote hyperkeratinisation, resulting from abnormal keratinisation of infundibular epithelium. Therefore, developing novel cosmetic active for acne, by targeting a diverse range of pathological factors is of particular importance. Pronounced properties of Rhodomyrtus tomentosathrough the molecules of interest it contains suggest a path towards developing a novel anti-acne agent. This is the method that Greentech used.
Acne vulgarisis an inflammatory and multifactorial skin disease1affecting more than 85% of adolescents and often continuing into adulthood.2The majority of epidemiologic studies of acne have focused on adolescents. Those who have studied adult acne reported a higher prevalence of acne among male patients before the age of 16 years, but a higher prevalence among female patients after the age of 23 years. The overall prevalence of acne does decline with age in both sexes, but it is clear that a significant number of individuals experience either a worsening of acne symptoms or fail to experience improvement after the teenaged years.
Moreover, although most epidemiological data in Western countries concern Caucasian skin types, acne is also a significant problem for Asian skin. In fact, in one large intercontinental epidemiological study among women, the prevalence of clinical acne was reported to be similar between geographical zones, 24% in Caucasian, 30% in Asian and 23% in continental Indian women. However, acne type was found to vary between skin subtypes. Asian women were reported to have a higher prevalence of infammatory acne than comedonal acne (20% vs 10%), compared to Caucasian women, for whom comedonal acne was more prevalent (14%) than infammatory acne (10%).3
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