The reduction of conspicuous facial pores is of great interest in cosmeceuticals. We evaluated the effect of fullerene application on conspicuous facial pores by using the VISIA system and by microscopic observation in a clinical trial.
. The fullerene lotion remarkably reduced the conspicuous facial pores over 8 weeks. To investigate the mechanism by which fullerene reduces facial pores, we examined its effects in suppressing ultraviolet B (UVB)-induced prostaglandin E2 (PGE2) production using reconstructed human epidermis (RhE). UVB irradiation of RhE increased PGE2 production, and the application of fullerene significantly suppressed the UVB-induced PGE2 production. These results suggest that 8 weeks of treatment with fullerene can reduce conspicuous facial pores, possibly through the suppression of PGE2 production in the epidermis. In addition, fullerene is thought to contribute to the prevention of lipid peroxidation through its radical scavenging properties.
‘Conspicuous facial pores’ tend to be thought of as a problem specific to young individuals. It is certainly more common in teenagers and those in their 20s but older individuals may also have facial pores that are problematic. In fact, more than 70% of the middle-aged individuals and those in their 30s to those in their 60s responded as “concerned about facial pores”. Therefore, in recent years, this problem has drawn much attention from the cosmetics industry so as to develop measures against it.
Sebum is one of the causes of conspicuous facial pores. A positive correlation has been reported between the amount of sebum and the size of pores, and conspicuous facial pores in young people are closely associated with sebum and keratin plugs.
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