New biological strategy corrects cellulite

Due to its caffeine-like effect, Adiposlim treats existing cellulite by simultaneously restricting and eliminating fat storage in the adipocytes through the inhibition of free fatty acid production and lipolysis stimulation. The fat storing capability of adipocytes is decreased allowing cellulite reduction in just a month. Adipoless provides a preventative and innovative action against cellulite formation through an anti-adipogenesis mechanism that suppresses the maturation of new adipocytes. Each active ingredient can be incorporated into formulas individually or together for a complementary effect.

Within the skin layers, adipocytes are located in the hypodermis. In the body, adipocytes are responsible for the synthesis and storage of fat, which is necessary in maintaining proper energy balance, mobilising energy sources in response to hormonal stimulations, and commanding changes by signal secretions. These cells influence body functions such as metabolism, temperature regulation, etc. However, enlarged adipocytes appear as non-aesthetic cellulite. When food is ingested, it is converted into energy to meet the body’s current demand. Any excess undergoes lipogenesis where the triglycerides are broken down into free fatty acids to enter the adipose tissue, where eventually it reforms into triglycerides again to be stored in the adipocytes. Once the existing adipocyte reaches its storage limits, it signals for dormant pre-adipocytes to mature and join the active adipocytes. Ultimately, the adipocytes increase their capacity to store fat, which can lead to the unsightly cellulite. Adiposlim (now referred to as ‘the first active’) is able to treat the existing adipocytes by reducing and limiting its ability to store fat while Adipoless (now referred to as ‘the second active’) prevents the recruitment of new adipocytes through an innovative anti-angiogenesis action. With its lipoaminoacid structure, the first active reduces the fat storage capability of the adipocytes via the inhibition of free fatty acid entry and the purge of stored fats by lipolysis activation. First, in the lipogenesis phase, the first active blocks the function of the lipoprotein lipase, thus inhibiting the transformation of triglycerides into free fatty acids. Because this occurs, free fatty acids can enter the adipocyte for fat storage. Test results show that the first active significantly limits the amount of free fatty acids that are able to enter into the adipocytes, as illustrated in Figure 1. Secondly, the first active achieves a caffeine-like lipolytic activity by stimulating lipolysis causing the break down of triglycerides into free fatty acids, which is explained by an increase of cAMP, a key substance within the adipocytes for fats elimination. Figure 2 demonstrates the measurement of triglyceride lipolysis from female (average of 13 specimens) and male (1 specimen) adipocytes. In comparison to 0.01% pure caffeine, the first active can obtain similar results, but at a lower dosage of 0.0025%. To further show the lipolytic action, cAMP levels were observed via actual measurement (Fig. 3), PDE3 inhibition, and adrenergic receptor regulation. Finally, as the free fatty acids are released, they are recycled into energy as cellular ATP (Fig. 4) so they are not available to reform into triglycerides as is the case with caffeine.

In vivo results