Digital media interest in PDRN (polydeoxyribonucleotide) face serums has risen more than tenfold in the past year, according to New York beauty trend analysts Spate.
PDRN is a compound made of DNA fragments that help regenerate skin cells and promote healing.
These serums are known for enhancing overall complexion and reducing signs of ageing.
While most PDRN is traditionally sourced from salmon sperm, there are now vegan alternatives available — though the continued popularity of animal-derived versions shows that many consumers are still willing to prioritize results over cruelty-free claims.
“Interest in PDRN serums has surged more than 1000% over the past year, and across platforms,” said Spate.
“On TikTok, which owns 68.6% of the trend’s popularity share, the branded hashtag #rejuran averages 1.4 million weekly views, while #medicube sees 188.2K,” it added.
“While Korean brands are currently leading the charge, there’s definitely room for more players to enter the space.”
Spate also identified 'Centella ampoule' as another face serum search undergoing a surge in interest.
It is a highly concentrated treatment known to repair and strengthen the skin barrier, calm redness, and reduce irritation.
“This trend has grown by +135.7% compared to last year, and across platforms. On Google Search, it’s up +161.6%, with 5.6K average monthly searches.
“TikTok is also fueling the conversation, with views up +69.3% year over year and averaging 672.7K weekly. While TikTok plays a key role, Google Search dominates the trend with 79.8% of the popularity share, showing that users are still turning to search for deeper skincare research.”
Korean brands like Skin1004 and PureHeal are appearing in top search queries, but the most searched term is not branded (centella ampoule), says Spate.
“That leaves an opportunity for new players to enter the market and set themselves apart, whether through branded content or a stronger focus on their soothing and hydrating benefits.”
